Baoliang Song

Wuhan University,China

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Rui-Ping Xiao

Peking University,China

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Yong Tae Kwon

Seoul National University, Republic of Korea

Research Area: 
Protein degradation, ubiquitin-proteasome system, autophagy-lysosome system, targeted protein degradation, drug development 

Selected Publications (H-index 49, i10-index 96, total publication ~150) 
1. Shim, S.M. et al. (2022) The Cys/N-degron pathway modulates pexophagy through the N-terminal oxidation and arginylation of ACAD10. Autophagy (in press) 
2. Ji, C.H. et al. (2022). The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system Nat Comms. 13:904. 
3. Ji C.H. et al. (2022) Targeted protein degradation via the autophagy-lysosome system: AUTOTAC (AUTOphagy-TArgeting Chimera). Autophagy 18:2259-2262. 
4. Lee, Y.J. et al. (2022) Chemical modulation of SQSTM1/p62-mediated xenophagy that targets a broad range of pathogenic bacteria. Autophagy (Mar 22)  
5. Heo, A.J. et al. (2022) The N-terminal cysteine is a dual sensor of oxygen and oxidative stress. Proc. Natl. Acad. Sci. USA. 118:e2107993118 
6. Lee, S.H. et al. (2021) p62/SQSTM1-induced caspase-8 aggresomes are essential for ionizing radiation-mediated apoptosis. Cell Death Disease 12:997 
7. Ji, C.H. et al. (2020) Regulation of reticulophagy by the N-degron pathway. Autophagy 16:373-375 
8. Ji, C.H. et al. (2019) The N-degron pathway mediates ER-phagy. Mol. Cell 75:1058-1072
9. Zhang, Y. et al. (2019) ZZ-Dependent regulation of p62/SQSTM1 in autophagy. Nat. Comms. 9:4373 
10. Lee, D.H. et al. (2018) DJ-1 modulates autophagic proteolysis through binding to the N-terminally arginylated form of the molecular chaperone BiP. Autophagy 14:1870-1885
11. Yoo, Y.D. et al. (2018) N-terminal arginylation generates a bimodal degron that modulates autophagic proteolysis. Proc. Natl. Acad. Sci. USA. 115:E2716-E2724.
12. Cha-Molstad, H. et al. (2017) p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway, which modulates autophagosome biogenesis. Nat. Comms. 8:102-125.

Nirma Samarawickrema

Monash University, Melbourne, Australia

Associate Professor Nirma Samarawickrema is a teaching-intensive academic from Monash University, Australia. At Monash, she teaches Biochemistry to students enrolled in the Bachelor of Medical Science and Doctor of Medicine, Bachelor of Biomedical Science, Bachelor of Science and Bachelor of Nutritional Science, and has successfully adapted her teaching to accommodate large classes. She has made major contributions to curriculum design and development of innovative teaching practices as well as to education research, where she has focused on pedagogical investigations to improve student learning. She is currently a member of our Department’s Education Management Group and the Chair of the Education Special Interest Group of the Australian Society for Biochemistry and Molecular Biology (ASBMB). In recognition of her extensive contribution to teaching, learning and scholarship, she was made a Fellow of the Monash Education Academy in 2017, a Fellow of the Higher Education Research and Development Society of Australasia in 2019 and judged the winner of the ASBMB Education Award for 2020.

Hidenori Ichijo

The University of Tokyo, Japan

Prof. Hidenori Ichijo’s research group is based at The University of Tokyo (http://www.f.u-tokyo.ac.jp/~toxicol/html/member/ichijo.html), Japan. He performed his PhD at the Tokyo Medical and Dental University. In 1998, he became professor and PI at the Tokyo Medical and Dental University. His research activities focus on molecular mechanisms of stress signaling represented by ASK family kinases. Prof. Ichijo’s work has been published in more than 290 articles and has been cited over 35,000 times, with an h index of 92.

IKURO ABE, Ph. D.

Graduate School of Pharmaceutical Sciences, The University of Tokyo

Ikuro Abe is Professor of Natural Products Chemistry at Graduate School of Pharmaceutical Sciences, The University of Tokyo (2009-). He received his B.S. (1984) and Ph.D. (1989) from The University of Tokyo. After two years postdoctoral research with Professor Guy Ourisson at the CNRS Institut de Chimie des Substances Naturelles, and mostly with Professor Michel Rohmer at the Ecole Nationale Supérieure de Chimie de Mulhouse in France (1989-1991), he moved to the USA to work with Professor Glenn D. Prestwich at the State University of New York at Stony Brook (1991-1996) and then at The University of Utah (1996-1998). His research interests mostly focus on exploring and engineering the natural products biosynthesis. He has authored 300+ publications including Nature, Nat. Catal., Nat. Chem., Nat. Chem. Biol., Nat. Commun., JACS, ACIE, and PNAS. He received the Pharmaceutical Society of Japan Award in 2019, and Prizes for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology, Japan. He is a former President of The Japanese Society of Pharmacognosy.

Hiroyasu Onaka

The University of Tokyo,Japan

Hiroyasu Onaka received his B.S. from the University of Tokyo (1993), Ph.D. from the University of Tokyo (1998). From 2012, he became a specially-appointed Professor at the Graduate school of Agricultural and Life Sciences, The University of Tokyo. The current research interests are (i) biosynthesis of RiPPs, which is a liner peptide including thiazole and oxazole rings (ii) development of drug screening from natural compounds with combined-culture. He was awarded Omura Award from the Society for Actinomycetes Japan (2022). The Sumiki-Umezawa Memorial Award from the Japan Antibiotics Research Association (2016). Toyama Award from Toyama Prefecture Citizens’ Personal Development Foundation (2010).

Osami Shoji

Nagoya University/University of Tokyo,Japan

Osami Shoji (born 1975 in Yamaguchi, Japan) received his BSc (1997), MSc (1999), and PhD (2002) in polymer chemistry from Chiba University under the direction of Prof. Takayuki Nakahira. He then joined Prof. Yoshiaki Kobuke at NAIST as a postdoctoral fellow, whereafter he joined Prof. Yoshihito Watanabe as a postdoctoral fellow at Nagoya University in 2005 and selected as a JSPS postdoctoral fellow in 2006. He was appointed assistant professor in 2008, promoted to associate professor in 2013, and anointed full professor in 2019 at the Graduate School of Science, Nagoya University. His research interests include construction and characterisation of artificial metalloproteins.

Jinpeng Sun

Shandong University, China

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Yanli Wang

Institute of Biophysics, CAS, China

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Yihua Chen

The Institute of Microbiology of the Chinese Academy of Sciences (IMCAS) ,China

Dr. Yihua Chen received his Ph.D. degree in Biochemistry and Molecular Biology at the Institute of Microbiology, Chinese Academy of Sciences in 2005. He undertook five years of postdoctoral studies at University of Wisconsin-Madison with Prof. Ben Shen in natural product biosynthesis. Since 2011, he has been a Research Group Leader in the Institute of Microbiology, Chinese Academy of Sciences, and is currently professor and vice-director of State Key Laboratory of Microbial Resource, China. His research lies at the crossroads of bacterial genetics and natural product chemistry, with emphasis on biosynthetic mechanisms of bacterial natural products and discovery of new small molecule drug leads through synthetic biology and genome mining.

Shaobo Dai

Shanghai Jiao Tong University

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Michael Landsberg

Group Leader and Associate Professor of Structural Biology and Biophysics
School of Chemistry and Molecular Biosciences
The University of Queensland

Michael Landsberg obtained his PhD in 2003 following which he embarked on a postdoc with Prof. Ben Hankamer (Institute for Molecular Biosciences) working as part of one of the first research groups in Australia to embrace electron cryo-microscopy (cryo-EM) as a tool for studying previously intractable biomolecular targets. His research since has come to focus on employing cryo-EM alongside complementary structural and biophysical methods to investigate fundamental molecular mechanisms defining the functional roles multiprotein complexes play in cellular homeostasis and disease. This work has helped illuminate mechanisms associated with bacterial pore-forming proteins, the assembly of viruses and virus-like particles, signalling cascades that contribute to innate immune responses and enzymes that regulate essential biosynthetic pathways. He was formally appointed as a group leader in the School of Chemistry and Molecular Biosciences at UQ in 2016, where he was promoted to Associate Professor in 2019 and was granted tenure in 2020. Alongside his own group’s research, he also currently leads SCMB’s Research Theme in Structural Biology and Biochemistry.

Zengyi Chang

Peking University, China

Zengyi Chang (昌增益) received his Ph.D. degree in Biochemistry in 1992 from Baylor College of Medicine in USA, and then spent three years (1992-1995) as a postdoctoral fellow at the Howard Hughes Medical Institute (HHMI). In 1996, he returned to China and worked as an associate professor in the Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China. In 1998, he was promoted to the full professor position in Biochemistry and Molecular Biology; in 2003 he moved to Peking University, Beijing, China. At Peking University, he has been serving as the director of the Center of Protein Sciences since 2005 and vice dean of the School of Life Sciences between 2007 and 2013. 

He has been serving as an Editor of Biochemical and Biophysical Research Communication (since 2013), an Associate Editor of Protein Science (since 2018); He also served as an editorial board member of the Journal of Biological Chemistry (for 5 years) and IUBMB Life, the executive vice Editor-in Chief of Science China Life Sciences (for 10 years). He is currently an Executive Committee member of the International Union of Biochemistry and Molecular Biology (IUBMB), Chief Supervisor of the Chinese Society of Biochemistry and Molecular Biology. He served as the President of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB), an Executive Council member of the Protein Society, the president of the Asia Pacific Protein Association (APPA), vice president of the Chinese Society of Biochemistry and Molecular Biology, President of the Chinese Protein Society. 

He has been conducting research in the field of protein function, mechanism and regulation, as well as the biogenesis and quality control of membrane proteins. His lab is also conducting research on the molecular mechanism of dormancy using bacteria and worms as model organisms. He has published over 110 papers.

Maojun Yang

Tsinghua University, China

Maojun Yang, Professor, School of Life Sciences, Tsinghua University. We are mainly engaged in the research on the structure and function of proteins related to cell sensing external signals and cell energy metabolism by means of structural biology combined with cell and molecular biology and biochemistry, and carries out drug design and clinical application research based on the high-resolution structure of these biomacromolecules. We have published more than 80 SCI papers. Since joining Tsinghua University in 2008, he has successively published more than 50 corresponding author SCI papers in Science, Nature and Cell et.al.. The supercomplexes and megacomplexes of electron transfer chain of mammalian and ATP synthase have been found, and their high resolution structures have been reported, which lays a good foundation for the development of related drugs. Among them, the research achievements in 2016 were selected as one of the top ten advances in China's life sciences in 2016 by the China Association for Science and Technology and the 2016 China Annual Paper by Cell Press. The 2017 Cell paper was highlighted by the internationally renowned "World Science and Technology Research News Information Network (physics. org)".

Jilong Liu

ShanghaiTech University, China

Professor Ji-Long Liu set up his laboratory at the University of Oxford in 2007 and joined ShanghaiTech University in 2016. In 2010, Professor Liu discovered that CTP synthase is compartmentalised into the cytoophidium (cell snake), a novel membraneless organelle. Studying multiple organisms including fruit flies, yeast and mammals, the Liu lab is keen to learn everything about the cytoophidium.

Hiroyuki NOJI

The University of Tokyo, Japan

Professor Hiroyuki Noji, a Professor of the Department of Applied Chemistry, The University of Tokyo, is a Single-Molecule Biophysicist. He has been studying the chemomechanical coupling mechanism of FoF1 ATP synthase using single-molecule techniques. He is also known as an inventor of the femtoliter chamber array system for single-molecule enzymatic assays that is currently applied in digital bioassays including single- molecule digital ELISA. He is the president of Biophysical Society of Japan (2021-2023).

Lawrence Lee

University of New South Wales, Australia

Lawrence Lee was trained as a structural biologist, specialising in X-ray crystallography during his PhD at Sydney University then as a Postdoc at the Victor Chang Cardiac Research Institute. Following this, Lawrence received a EMBO fellowship at the University of Oxford while establishing an independent research group focused on utilising biomolecules to explore and harness molecular self-assembly in novel synthetic systems. Lawrence is currently employed as a Group Leader and Associate Professor at the EMBL Node for Single Molecule Science at the University of New South Wales, Sydney, and a Chief Investigator in the ARC Centre of Excellence in Synthetic Biology. He has been recognised numerous awards and honours including an ARC Discovery Early Career Research Award, the National Association of Research Fellows Young Investigator of the Year and a NSW Tall Poppy Award.

Michael Landsberg

The University of Queensland, Australia

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Atsushi SHIBATA

Gunma University,Japan

Research interests 
DNA double strand break repair 
DNA damage signaling and immune response in cancer therapy

Representative publications (not more than 5) 
Yuki Uchihara et al., & Atsushi Shibata* DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production Molecular Cell, 82(14):2557-2570, 2022 
Takaaki Yasuhara#*, Reona Kato# et al., Atsushi Shibata* & Kiyoshi Miyagawa*. Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair. Cell, 175 (2):558-570, 2018.
Hiro Sato et al., & Atsushi Shibata*. DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells Nature Communications, 8(1):1751, 2017.
Mayu Isono et al, & Atsushi Shibata*. BRCA1 directs the repair pathway to homologous recombination by promoting 53BP1 dephosphorylation. Cell Reports, 18(2):520-532, 2017.
Atsushi Shibata et al. DNA Double Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities. Molecular Cell, 53 (1), 7-18, 2014.

Makoto NAKANISHI

University of Tokyo,Japan

Research and Professional Experience: 
April, 2019-present: Vice Dean, Institute of Medical Science, The University of Tokyo 
April, 2016-present: Professor, Division of Cancer Cell Biology, Institute of Medical Science, The University of Tokyo 
June, 2012-March, 2015: Advisor to the President, Nagoya City University 
April, 2011-March, 2016: Vice Dean, Medical School and Graduate School of Medical Sciences, Nagoya City University 
April, 2002-March, 2016: Professor and Chair at Department of Cell Biology, Graduate School of Medical Sciences, Nagoya City University 
Sept., 2000-March, 2002: Professor and Chair at Department of Biochemistry, Nagoya City University Medical School 
July, 1998-Aug., 2000: Associate Professor at Department of Biochemistry, Nagoya City University Medical School 
April, 1996- June, 1998: Chief, lab. of Drug Development at Department of Geriatric Research, National Institute for Longevity Sciences 
Feb., 1992- March, 1996: Lecturer at Department of Biochemistry, Jichi Medical School 
March, 1993- Feb., 1995: Research Associate, Huffington Center on Aging and Division of Molecular Virology, Baylor College of Medicine, U.S.A. 
April, 1989- Jan., 1992: Research Assistant Professor at Department of Biochemistry, Jichi Medical School

Tomoo OGI

Nagoya University,Japan

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Xiaochun Yu

Westlake University, China

Research interests 
DNA damage response, genomic instability 

Representative publications (5 from 102 peer-reviewed publications)  
Gai X, Xin D, Wu D, Wang X, Chen L, Wang Y, Ma K, Li Q, Li P, Yu X. (2022) Pre-ribosomal RNA reorganizes DNA damage repair factors in nucleus during meiotic prophase and DNA damage response. Cell Res. 32：254-268 
Singh AK and Yu X. (2020). Tissue-specific carcinogens as soil to seed BRCA1/2-mutant hereditary cancers. Trends Cancer 6:559-568 
Li, M. and Yu, X. (2013) Function of BRCA1 in the DNA damage response is mediated by ADP-ribosylation. Cancer Cell. 23:693-704. 
Chen, Q., Chen, Y., Bian, C., Fujiki, R. and Yu, X. (2013) TET2 promotes histone O- GlcNacylation during gene transcription. Nature 493:561-564. 
Kim, H., Chen, J. * and Yu, X. * (2007). Ubiquitin-binding protein RAP80 mediates BRCA1- dependent DNA damage responses. Science, 316, 1202-1205. (* co-corresponding authors)

Wei-guo Zhu

Shenzhen University, China

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Xingzhi Xu

Shenzhen University, China

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Guoliang Xu

Centre for Excellence in Molecular Cell Science, CAS, China

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Bing Zhu

Institute of Biophysics, CAS, China

Bing Zhu, Ph.D., investigator and deputy director of the Institute of Biophysics, Chinese Academy of Sciences. His lab is interested in understanding how epigenetic system helps our cells to remember their past and to prepare for the future. Dr. Zhu is an internationally recognized scientist. Dr. Zhu serves as a member of the Board of Reviewing Editors of the Science magazine starting from 2020.

Feilong Meng

Centre for Excellence in Molecular Cell Science, CAS, China

Fei-Long Meng, obtained his PhD in Biochemistry and Molecular Biology at Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences at 2009. After postdoctoral fellowship in Harvard Medical School, he became a Principal Investigator at Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences; University of Chinese Academy of Sciences since 2015. His research has focused on the mechanisms of antibody diversification in B lymphocytes, including antibody class switch and affinity maturation. His lab aims to understand the molecular mechanisms underlying specific-targeting cytidine deaminase AID, error-prone decoding of DNA lesions, and affinity-based selection of B cells. Furthermore, they seek to establish new methods for antibody generation and discovery. In this course, they have revealed genomic and epigenomic features of AID targeting, identified critical regulator of orientation-specific DNA recombination, and invented a set of antibody ex vivo affinity maturation and selection methods.

Fei Chen

Instittues of Biomedical Sciences Fudan University,China

Dr. Fei Chen is a Principal Investigator of the Institute of Biomedical Sciences (IBS) and Shanghai Cancer Center at Fudan University. His lab studies the fundamental principles of transcriptional and epigenetic regulations and their functions in development and disease.

Jun-An Chen

Academia Sinica, Taipei, China

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Naoki Kubo

Kyushu University,Japan

2007 M.D. Kyushu University School of Medicine 
2007-2012 Clinical jobs (Respiratory medicine) at several hospitals in Japan 
2012-2016 Ph.D. Medical Institute of Bioregulation, Kyushu University (Dr. Hiroyuki Sasaki’s Lab) 
2016-2021 Postdoctoral Researcher, University of California, San Diego, (Dr. Bing Ren’s Lab) 
2021- Assistant Professor, Medical Institute of Bioregulation, Kyushu University (Dr. Hiroyuki Sasaki’s Lab)

Hong Cheng

Centre for Excellence in Molecular Cell Science, CAS, China

Hong Cheng, Ph.D., is a Professor in Shanghai Institute of Biochemistry and Cell Biology. She received his undergraduate degree from China Medical University and Ph.D. degree from Kobe University, and performed postdoctoral studies at Harvard Medical School. 

The Cheng lab studies how nascent RNAs are sorted into the nuclear export, degradation and retention pathways. To understand this, the lab has been focused on studying three closely related aspects of gene expression: (1) The mechanism and regulation of nascent RNA sorting; (2) The complex interconnection between transcription, pre-mRNA processing and nuclear export; (3) Mechanisms and biological function of nuclear RNA degradation. Through these studies, the lab aims to reveal how the fate of nascent RNAs is determined and to understand the functional importance of RNA sorting.

Yueqin Chen

Sun Yat-sen University, China

Dr. Chen mainly focuses on the function of noncoding RNAs (ncRNAs). Her group has uncovered new and unexpected insights into RNA biology, specifically in cell fate and organism development, for example, orphan snoRNAs in cell differentiation via a non-canonical complex, and chromatin binding lncRNAs in genome stability and DNA repair, etc. Recently, her group also found the non-classical translation capacity of lncRNAs to code micropeptide and regulate translation machinery. The related results have been published in Nature Biotechnology（cover story）、Molecular Cell（cover story）、PNAS, etc.

Chien-Ling Lin

Institute of Molecular Biology, Academia Sinica, Taipei, China

RESEARCH INTEREST 
Genome-Wide Analysis of mRNA Splicing and Translation. 
RNA and Disease. 
Molecular Mechanism of Post-transcriptional Regulation

SELECTED PUBLICATIONS： 
1. Hung-Lun Chiang*, Yi-Ting Chen*, Jia-Ying Su*, Hsin-Nan Lin, Chen-Hsin Albert Yu, Yu-Jen Hung, Yun-Lin Wang, Yen-Tsung Huang and Chien-Ling Lin. Mechanism and modeling of human disease-associated near-exon intronic variants that perturb RNA splicing. Nat Struct Mol Biol. In press. (*contributed equally) 
2. Hsiao-Jung Kao, Hung-Lun Chiang, Hsiao-Huei Chen, Pi-Chuang Fan, Yi-Fang Tu, Yen-Yin Chou, Wuh-Liang Hwu, Chien-Ling Lin, Pui-Yan Kwok and Ni-Chung Lee. 2020. De novo mutation and skewed X-inactivation in girl with BCAP31-related syndrome. Human Mutation 41:1775-1782. https://doi.org/10.1002/humu.24080
3. Allison J Taggart*, Chien-Ling Lin*, Barsha Shrestha, Claire Heintzelman, Seong Won Kim and William G Fairbrother. 2017. Large-scale Analysis of Branchpoint Usage across Species and Cell Lines. Genome Research 27:639-649. (*contributed equally) https://doi.org/10.1101/gr.202820.115
4. Chien-Ling Lin, Allison J. Taggart, William G. Fairbrother. 2016. RNA Structure in Splicing: an Evolutionary Perspective. RNA Biol. 13:766-771. https://doi.org/10.1080/15476286.2016.1208893
5. Chien-Ling Lin*, Allison J. Taggart*, Kian Huat Lim*, Kamil J. Cygan, Luciana Ferraris, Robbert Creton, Yen-Tsung Huang, and William G. Fairbrother. 2016. RNA structure replaces the need for U2AF2 in splicing. Genome Research 26:12-23. (*contributed equally) https://doi.org/10.1101/gr.181008.114

Chengqi YI

Peking University, China

RESEARCH INTERESTS 
1. RNA modifications and epitranscriptomics; 
2. Development of novel RNA base editing technologies; 
3. Off-target evaluation of genome editing tools; 
4. Chemical biology of RNA/DNA modifications.

Polly Chen

Cancer Science Institute of Singapore, National University of Singapore, Singapore

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Mikiko C Siomi

The University of Tokyo, Japan

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Jie Luo

Wuhan University, China

Jie Luo obtained her B.S. from the College of Life Sciences, Wuhan University in 2003, and Ph.D. from the Department of Physiology and Neurobiology, University of Connecticut in 2010. She then did her postdoctoral training in the Department of Pharmacology, University of Washington till 2014. She is now a professor of biochemistry at Wuhan University. Dr. Luo’s research focuses on the mechanisms underlying cholesterol metabolism and cholesterol-related diseases. Her findings include 1) discovery of plasma prekallikrein (Circulation 2022), POST1 (Protein Cell 2021) and SUMO-specific peptidase 1 (J Biol Chem 2021) as the regulators of cholesterol uptake; 2) discovery of IDOL (G51S) as a causal factor for hypercholesterolemia (Arterioscler Thromb Vasc Biol 2019); 3) elucidation of the mechanism by which TM6SF2 (E167K) mutation drives nonalcoholic fatty liver disease and how UBIAD1 mutations result in Schnyder corneal dystrophy (PLOS Genet 2019, 2020); and 4) development of a PROTAC-based degrader of HMGCR for the treatment of hypercholesterolemia (J Med Chem 2020). Dr. Luo has also published reviews in Nat Rev Mol Cell Biol, Trends Biochem Sci, Life Metab and many other journals.

Xiao-Wei Chen

Peking University, China

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Feng-Jung Chen

Fudan University, China

Recent Topic: 
CIDE family proteins-mediated lipid droplet fusion and growth

Feng-Jung Chen has long been committed to studying the dynamics of lipid droplets, which are dynamic cellular organelles for neutral lipid storage. The changes in LD size and number are related to the lipid metabolism under physiological conditions, which depends on the protein expression on LD, the growth mode of LD, and lipolysis caused by lipase activity. In terms of intracellular LD growth, CIDE protein-mediated LD fusion is the main growth mode of LD in adipocytes and hepatocytes. However, the molecular mechanism of LD fusion is still unclear, and there is still a lack of useful technology to study the subject. We have proposed biophysical modeling and developed five biophysical technologies, such as fluorescence recovery after photobleaching (FRAP)-based lipid exchange rate assay, differential interference contrast (DIC) microscopy-based lipid transfer rate assay, fluorescence correlation spectroscopy (FCS), transmission electron microscopy (TEM), and stochastic optical reconstruction microscopy (STORM) imaging, to study the kinetics of CIDE protein phase separation and condensation and the dynamics of phase separation-generated fusion plates at LD-LD contact sites. Recently, we have preliminarily uncovered the molecular mechanism of the CIDE protein condensation and revealed the versatility of protein phase separation for lipid storage.

Recent Publications: 1. G. Tang†, C. Ma†, L. Li, S. Zhang, F. Li, J. Wu, Y. Yin, Q. Zhu, Y. Liang, R. Wang, H. Huang, T.-J. Zhao, H. Yang, P. Li, and F.-J. Chen*. PITPNC1 promotes the thermogenesis of brown adipose tissue under acute cold exposure. (2022) SCIENCE CHINA-Life Sciences. In press. (†Co-first authors) doi: 10.1007/s11427-022-2157-y

2. X. Lyu†, J. Wang†, J. Wang†, Y. Yin, Y. Zhu, L.-L. Li, S. Huang, S. Peng, B. Xue, R. Liao, S.-Q. Wang, M. Long, T. Wohland, B.T. Chua, Y. Sun, P. Li, X.-W. Chen, L. Xu, F.-J. Chen*, and P. Li*. A gel-like condensation of Cidec generates lipid-permeable plates for lipid droplet fusion. (2021) Developmental Cell. 56:2592–2606. (†Co-first authors; *Co-corresponding authors)

Jae Bum Kim

Seoul National University, South Korea

Dr. Jae Bum Kim is a Professor of Biological Sciences at Seoul National University and Director of the Center for Adipocyte Structure and Function, National Leading Research Initiatives in Korea. He obtained his Bachelor and Master’s degree in Science at Seoul National University. Then, he earned his Ph. D. at Harvard University under the mentorship of Dr. Bruce Spiegelman, where he cloned and elucidated ADD1/SREBP1c as a key lipogenic transcription factor. After his postdoctoral fellowship training with Dr. Phillip Sharp at MIT, he joined at School of Biological Sciences, Seoul National University in 2000. His research group has investigated gene expression regulation and signal transduction pathways of lipid and glucose metabolism. Recently, his group has focused on the molecular mechanisms of adipose tissue heterogeneity, immune response, and insulin resistance, which would shed important insights on obesity and its related metabolic diseases.

David Silver

Duke-NUS Medical School, Singapore

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Jae Bum Kim

Seoul National University, Republic of Korea

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Yong Liu

Wuhan University, China

Dr. Yong Liu received his Bachelor and Master degrees in Biochemistry from Peking University in 1986 and 1989, respectively. He obtained his Ph.D. degree in 1995 in Microbiology and Molecular Genetics from Rutgers-The State University of New Jersey and UMDNJ-RWJ Medical School. After his post-doctoral training at University of California, Santa Barbara from 1995 to 2000, Dr. Liu worked as a Senior Scientist at the Immunology Section of AlleCure/Mankind Corp., a California-based biotechnology company. In 2003, Dr. Liu joined the Institute for Nutritional Sciences as a Principal Investigator at SIBS, Chinese Academy of Sciences in Shanghai. In 2015, he moved to Wuhan and joined the College of Life Sciences at Wuhan University. 

Dr. Liu’s research focuses on the molecular and cellular mechanisms that link cellular ER stress to the pathogenesis of metabolic and inflammatory diseases. In particular, his research group aims to elucidate the role of the ER stress sensor IRE1α in obesity, diabetes, NASH, sarcopenia as well as certain cancers.

Yih-Cherng Liou

The National University of Singapore, Singapore

Dr. Yih-Cherng Liou is an Associate Professor in the Department of Biological Sciences, National University of Singapore (NUS). He obtained his B.Sc. in the Department of Food Science from the National Taiwan Ocean University. He then completed his Ph.D. degree in the Department of Biochemistry at the Queen’s University, Kingston, Canada. He then joined Dr. Kun Ping Lu’s group, as a post-doctoral fellow, at the Beth Israel Deaconess Medical Center, Harvard Medical School, working on the roles of peptidyl prolyl isomerases in cancer and Alzheimer’s disease. He joined the Department of Biological Sciences, NUS as a faculty in 2003. In addition to peptidyl prolyl isomerase, recently his group has extended their interests into the functions of mitochondrial outer membrane proteins in regulating mitochondrial dynamics and quality controls. His recent work has made seminal contribution to the field. Furthermore, to contribute the research society, he is also actively involved in several editorial boards of Journals.

Sun Lei

Duke-NUS medical school Singapore, Singapore

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Yanchuan Shi

Garvan Institute of Medical Research, Sydney, Australia

A/Prof Yanchuan Shi (Yan) is a medically trained scientist, currently group leader of the Obesity and Metabolic Disease Research Group at the Garvan Institute of Medical Research. She is conjoint Associate Professor within School of Clinical Medicine, St Vincent’s Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Australia. 

Dr Shi obtained her Bachelor’s degree in Medicine in China; She came to IMVS/Royal Adelaide Hospital on a WHO fellowship as a visiting scholar, and commenced her PhD in bone and skeletal research at UNSW Sydney where she received her PhD in 2006. Dr Shi started her post-doctoral training at the Eating Disorders Research Laboratory within the Neuroscience Division at Garvan. She was promoted to Group Leader of Neuroendocrinology in 2014, leading her independent research, which has been supported by the NHMRC and DART grants. While working as a full-time researcher, she also successfully requalified for her Australian medical licence in 2012. 

Dr Shi’s research focus encompasses the neuroendocrine regulation of food intake, adipose tissue thermogenesis & metabolism, insulin secretion & glucose homeostasis, with a special emphasis on centrally and peripherally-produced neuropeptide Y family members.

Ying Liu

Peking University, China

Dr. Ying Liu is a Professor and Associate Dean of College of Future Technology, Peking University. She also holds positions as an HHMI International Research Scholar and a principal investigator of Center for Life Sciences. She received her B.S. degree in Biotechnology from Nanjing University and Ph.D. degree in Biochemistry from the University of Texas Southwestern Medical Center. She then pursued her postdoctoral training at Massachusetts General Hospital. Dr. Liu received many awards including the Xplorer Prize and China Young Female Scientist Award.

Yiguo Wang

Tsinghua University, China

RESEARCH INTERESTS 
Hormonal Regulation of Energy Homeostasis 

SELECTED PUBLICATIONS 
1. Yang Liu#, Aijun Long#, Liqun Chen, Liangjie Jia and Yiguo Wang*. (2020) The Asprosin-OLFR734 module regulates appeptitive behaviors. Cell Discov. 6, 19. 
2. Yi Liu#, Yuanyuan Zhang#, Tong Li, Jinbo Han and Yiguo Wang*. (2020) The tight-junction protein TJP1 regulates the feeding-modulated hepatic circadian clock. Nat Commun. 11(1), 589. 
3. Erwei Li#, Haili Shan#, Liqun Chen#, Aijun Long#, Yuanyuan Zhang#, Yang Liu, Liangjie Jia, Fangchao Wei, Jinbo Han, Tong Li, Xiaohui Liu, Haiteng Deng and Yiguo Wang*. (2019) OLFR734 mediates glucose metabolism as a receptor of Asprosin. Cell Metab. 30, 319-328. 
4. Yuanyuan Zhang, Lina Xu, Xiaohui Liu* and Yiguo Wang*. (2018) Evaluation of insulin sensitivity by hyperinsulinemic-euglycemic clamps using isotope-labelled glucose. Cell Discov. 4, 17. 
5. Liqun Chen#, Ke Wang#, Aijun Long, Liangjie Jia, Yuanyuan Zhang, Haiteng Deng, Yu Li, Jinbo Han and Yiguo Wang*. (2017) Fasting-induced hormonal regulation of lysosomal function. Cell Res. 27, 748-763. 
6. Jinbo Han#, Erwei Li#, Liqun Chen, Yuanyuan Zhang, Fangchao Wei, Jieyuan Liu, Haiteng Deng and Yiguo Wang*. (2015). The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1. Nature 524, 243-246. 
7. Yiguo Wang, Gang Li, Jason Goode, Jose C. Paz, Kunfu Ouyang, Robert Screaton, Wolfgang H. Fischer, Ju Chen, Ira Tabas and Marc Montminy*. (2012). InsP3 receptor regulates hepatic gluconeogenesis in fasting and diabetes. Nature 485, 128-132.
8. Yiguo Wang, Hiroshi Inoue, Kim Ravnskjaer, Kristin Viste, Nina Miller, Yi Liu, Susan Hedrick, Liliana Vera, and Marc Montminy*. (2010). Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity. Proc Natl Acad Sci U S A. 107, 3087-3092.
9. Yiguo Wang, Liliana Vera, Wolfgang H Fischer, Marc Montminy*. (2009). The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 460, 534-537.

Tong-Jin Zhao

Fudan University, China

Dr. Tong-Jin Zhao obtained his Bachelor’s degree from Shandong University at 2002, and his PhD from Tsinghua University in 2007. From 2007 to 2014, he joined the Brown&Goldstein laboratory at UT Southwestern as a postdoctoral fellow and research assistant professor. In 2014, Dr. Zhao moved to School of Life Sciences at Xiamen University and worked as a professor. From 2019, he is professor at Institute of Metabolism & Integrative Biology (IMIB) of Fudan University. In 2022, he was supported by the National Science Fund for Distinguished Young Scholars. 

His laboratory mainly focuses on dissecting the molecular mechanism of the metabolic diseases. They are currently working on the regulatory mechanism of fatty acid sensing and uptake. Dr. Zhao has published a series of research articles, including Cell Metabolism, PNAS, Cell reports and Nature Communications.

Xu Chen

University of California, San Diego, La Jolla, CA, USA

Dr. Xu Chen received her bachelor's degree from Peking University, School of Life Sciences. She did her PhD study at University of Wisconsin - Madison, followed by postdoctoral training at University of California, San Francisco. Dr. Chen recently joined faculty of Department of Neurosciences at University of California, San Diego. Her research is focused on understanding the pathophysiology and molecular mechanism underlying neurodegeneration, especially Alzheimer's disease.

Emily Shizhen Wang

Department of Pathology, UCSD,USA

S. Emily Wang, Ph.D., is a Professor at the University of California, San Diego. She first began her research career in the late 1990s as a virologist and obtained her doctorate from the University of Nebraska-Lincoln and Nankai University, followed by post-doctoral trainings at the Johns Hopkins University and Vanderbilt University. Dr. Wang’s group is currently exploring mechanisms through which cancer cell-derived extracellular vesicles contribute to the multifaceted reprogramming of non-cancerous cells in the host as well as novel therapeutic strategies targeting cancer-derived extracellular miRNAs for their function in cancer-host communication.

Changtao Jiang

Peking University, China, China

Dr. Jiang received a B.S. in clinical medicine and Ph.D. degrees from Peking University and completed postdoctoral training at the National Institutes of Health. In 2014, he established independent research group in the Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University. He was promoted to full professor with tenure and Boya distinguished professor at Peking University in 2020 and 2021 respectively. Dr. Jiang’s research mainly focuses on the pathogenesis and translational research of metabolic diseases, including focusing on the role of the ceramide and gut microbial metabolic network in metabolic disorders. He proposes a new theory of "Intestine as the Target in Treating Metabolic Diseases". He discovers the role of bile acids and ceramide in mediating host-gut microbiota crosstalk in the pathogenesis of metabolic diseases and reveals intestinal FXR, HIF-2α, SMPD3, TGR5 and IL-22 as new targets for the intervention of metabolic diseases. Dr. Jiang has published 22 SCI papers in Nature (2022), Nature Medicine (2017, 2018, 2019), Cell Metabolism (2019, 2021a, 2021b), the Journal of Clinical Investigation (2021), Diabetes (2016) and others as the corresponding author, in which 2 papers are highly cited (Top 1%, Web of Science). He has published 4 reviews in Nature Reviews Endocrinology, Gastroenterology, Protein & Cell, and Small Methods, and hold 4 patents. He received the Distinguished Young Scholar of the National Natural Science Foundation, the 16th China Youth Science and Technology Award, the 6th CADA Young Investigator Award, the 8th Shulan Medical Youth Award and the 23rd Mao Yisheng Beijing Youth Science and Technology Award.

Ping Gao

South China University of Technology (SCUT) ,China

Dr.Ping Gao is currently a professor and principle investigator at South China Univercity of Technology. His research interest is focused on cellular metabolism, cancer metabolism in particular, and has made numerous important discoveries in dissecting the mechanisms underlying cancer metabolic reprogramming. He has published more than 70 papers in such journals as Nature, Cancer Cell, Nature Cancer，Cell Metabolism, Nature Metabolism, Nature Communications, EMBO J, and Blood.

Min-Dian Li

Dr. Li graduated Summa Cum Laude from Peking University College of Life Sciences, and received his MPhil and PhD in Cellular and Molecular Physiology from Yale University. He had been a Glenn/AFAR postdoctoral fellow in Harvard University and a visiting scholar in Tsinghua University. His research focuses on circadian regulation of metabolism and physiology, which aims to define clock-modulated checkpoints connecting time-restricted eating and health. Representative works are published in Cell Metabolism, Trends in Cell Biology, etc.

Ruth Kluck

Walter and Eliza Hall Institute, Australia

A/Prof. Ruth Kluck is a laboratory head in the Blood Cells and Blood Cancer Division at The Walter and Eliza Hall Institute, Melbourne, Australia. She investigates apoptotic cell death, focusing on how the BCL2 protein family regulates mitochondrial permeabilization. As a postdoc in San Diego, her finding that BCL2 regulates apoptosis by maintaining mitochondrial integrity helped open a new area in apoptosis research. After moving to Melbourne, she discovered that two family members, BAX and BAK, transform into novel symmetric homodimers to generate the apoptotic pore, and identified several molecular changes involved in this transformation, as well as the ability of antibodies to activate or inhibit. Other studies have identified how BAX and BAK can be sequestered by the prosurvival BCL2 proteins to cause resistance to anti-cancer treatments.

Takaharu Sakuragi

WPI Immunology Frontier Research Center, Osaka Universit, Japan

Takaharu Sakuragi obtained M.D. from Kyoto University in 2013. 

He received a Ph.D. in medicine from Osaka University in 2019. From 2019, he worked as a postdoc at Immunology Frontier Research Center, Osaka University, where he was appointed an Assistant Professor in 2021. 

His research interests are in mechanisms of phospholipid scrambling and physiological roles of scramblases.

Kazunobu Sawamoto

Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, Japan

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Jingjin Ding

Institute of Biophysics, CAS, China

Dr. Jingjin Ding is a Principal Investigator of the Institute of Biophysics (IBP), Chinese Academy of Sciences. He received his B.S. degree in biotechnology from Wuhan University in 2003, and his Ph.D. degree in biochemistry and molecular biology from IBP in 2008. After completing a postdoctoral training with Prof. Da-Cheng Wang at IBP, he was appointed as a research assistant in 2010. From 2013 to 2017, he was a visiting scientist in Dr. Feng Shao’s lab at the National Institute of Biological Sciences, Beijing. In 2018, he started his own lab at IBP. Dr. Jingjin Ding was awarded as “Excellent Young Scholar” from the NSFC in 2019 and “Excellent Member” from the Youth Innovation Promotion Association of CAS in 2021. Research in Dr. Ding’s lab focuses on the host-pathogen interface. Using multi-disciplinary approaches his group has systematically explored the molecular mechanisms for Gasdermin-D (GSDMD) recognition and activation by upstream inflammatory caspases, and GSDMD-mediated pyroptotic cell death in innate immunity. His group also deciphers detailed mechanisms for bacterial effectors inactivation of host targets by virtue of novel post-translational modification.

Liming Sun

Centre for Excellence in Molecular Cell Science, CAS, China

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Ben Lv

Xiangya Hospital Central South University, China

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Shee Mei Lok

Duke-NUS Medical School, Singapore

Dr Shee-Mei Lok is a Provost Chair Professor in the Emerging Infectious program in Duke-NUS, Singapore. She was also a National Research Foundation (NRF) fellow (2009-2014) and is now a NRF Investigator. She is a structural virologist specializing in x-ray crystallography and cryo-electron microscopy. Her research interest focuses on the structural changes of flavivirus particles during its infection cycle and the effect of anti-viral therapeutics on them. She obtained her Msc and PhD in NUS and did her post-doctoral training in Purdue University under the supervision of the late Hanley Prof Michael Rossmann. Her laboratory made significant discoveries in the understanding of the structures of the Zika and dengue viruses, the morphological variants of dengue viruses, also how potent human antibodies neutralize flaviviruses and the structural changes of flavivirus during maturation.

Julien Lescar

Nanyang Technological University,Singapore

Julien Lescar (School of Biological Sciences, NTU, Director NTU Institute of Structural Biology) is a renowned expert in biochemistry and structural biology and has been working in Singapore for the last twenty years. He was instrumental in establishing macromolecular X-ray crystallography and structural biology at NTU. His laboratory is involved in research programs on the structural biology of infectious diseases and structure-based drug design.

Dong-Yan Jin

The University of Hong Kong,China

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Zhigao Bu

Harbin Verterinary Rsearch Institute, CAAS, China

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Yuelong Shu

Sun Yat-sen University, China

Dr.Yue-long Shu, Ph.D. is the Executive director of Institute of Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College(PUMC). He is also the Chair of APACI and the Fellow of American Academy of Microbiology.. 

Dr Shu finished his PhD studies in 1998, at the Institute of Virology, Chinese Academy of Preventive Medicine. He was a post-doctorate fellow at the Institute of Gene Therapy, Mount Sinai Medical School (1998–1999), and in Department of Molecular Pharmacology，Medical School of University of California, Los Angeles (1999–2002). He was the founding Dean of School of public health (Shenzhen), Sun Yat-sen University (2017-2022). He also served as the deputy director of the China Center for Disease Control and prevention (2008-2017), the director of the National Influenza Center (2004-2017), director of the Collaborating Center for Reference and Research on Influenza of World Health Organization (2010-2017). His research interests focus on the etiology and epidemiology of influenza, and has published more than 300 scientific papers, including more than 140 papers as corresponding authors published in top scientific journals such as Nature, NEJM, Science, Lancet et al. His scientific contributions including: (1) firstly identified novel H7N9, H10N8 and H5N6 avian influenza viruses caused human infections; (2) developed the 2009 pandemic H1N1 and the H7N9 avian influenza virus diagnostic reagents, providing key technology support for disease prevention and control; (3) leading the establishment of the world's biggest influenza surveillance and response network, which has become an important force in the prevention and control of influenza and novel pathogen identification of emerging infectious diseases. Dr. Shu was the winner of National Natural Science Foundation of China for distinguished Young Scholars, the first batch of talent candidates for national scientific and technological innovation, and the 2014 top ten most influential figures in "science and technology innovation" selected by the committee jointly organized by Chinese Academy of engineering and China Academy of Sciences and other 7 ministries in China.

Yi Shi

The Institute of Microbiology of the Chinese Academy of Sciences (IMCAS) ,China

Dr. Yi Shi works as a researcher in the Institute of Microbiology, Chinese Academy of Sciences (CAS). As the Executive Director of CAS-TWAS Center of Excellence for Emerging Infectious Disease (CEEID), Chinese Academy of Sciences, he has co-organized several academic and cooperation issues with the scientists in UK, USA, Australia, Russia, Brazil, and other countries. He is also the secretary-general of the Biological and Medical Sciences Committee of the Chinese Association of Young Scientists and Technologists, committee member of the Chinese Society of Immunology. His expertise mainly focuses on the molecular mechanism of pathogen infection and regulation by the host, and the interaction between receptors and ligands during immune response. He has made remarkable progress on the infection mechanism of a range of important human pathogens including influenza virus, Ebola virus, ZIKV, arenaviruses, and coronaviruses. He has published more than 100 refereed papers in the international academic journals including Cell, Nature, and Science.

Haitao Yang

ShanghaiTech University, China

杨海涛，教育部长江特聘教授，上海科技大学免疫化学研究所研究员，执行所长，担任了国家重点研发计划总体专家组专家、国家“重大新药创制”科技重大专项评审专家、法国国家科研署基金外审专家、波兰国家科学基金外审专家、香港特区政府研究资助局评审专家、苏黎世联邦理工学院（ETH）研究管理委员会外审专家、科技部全国颠覆性技术创新大赛评委、国家重点基础研究发展计划（973计划）青年项目首席科学家；担任了Nature、The Lancet Infectious Diseases、Nature Cell Biology、Cell Host & Microbe、Nature Chemical Biology、Science Translational Medicine、Nature Biomedical Engineering、Nature Communications、Science Advances、PLOS Pathogens、Angewandte Chemie、Chemical Science、Journal of Medicinal Chemistry、Journal of Virology、Current Opinion in Virology、ACS Catalysis、The Lancet's EBioMedicine、Journal of Antimicrobial Chemotherapy和Small Science等十余种国际知名杂志的审稿人。获得了中国产学研合作促进奖、中国侨界贡献奖、科学中国人年度人物、谈家桢生命科学创新奖、树兰青年医学奖、Promega Award for Biochemistry和药明康德生命化学杰出成就奖等奖项。

近期研究成果包括： 
1、在结核杆菌关键药物靶点的结构和药物发现的研究中取得进展，论文发表于Cell、Science等杂志，并入选2019年度“中国高校十大科技进展”和2019年度“中国生命科学十大进展”。 
2、在新型冠状病毒关键药物靶点的结构和药物开发的研究中取得进展，相关研究论文先后在Nature、Science（封面论文）、Cell、Nature Structural & Molecular Biology和PNAS等杂志发表，并在Cell和Nature Reviews Microbiology杂志上发表了特邀综述。以上成果入选2020年度富林沃斯（Falling Walls）生命科学领域十项进展、2020年度“中国生命科学十大进展”。 
3、揭示了沃尔巴氏菌(Wolbachia)感染蚊虫过程中诱导胞质不相容性CI(cytoplasmic incompatibility)的发生和拯救现象的普适分子机制，证实其符合毒素－抗毒素模型（TA model）（PNAS, 2021）；通过人工设计CI因子并调控它们间的相互作用，首次实现了人工操纵CI（Nature Communications, 2022）。以上成果对利用沃尔巴氏菌和CI防控蚊媒疾病和农业虫害奠定了基础，并被微生物领域权威期刊（Environmental Microbiology）邀请发表综述性论文（EMI, 2022）。

• Research Area: Infection and Anti-infection

• Research Interests: Viruses are significant pathogens involved in human diseases throughout human history. Many of these virus-related human diseases have zoonotic origins, such as AIDS, bird flu, and severe acute respiratory syndrome (SARS). We focus on the essential stages of the viral life cycle: cellular entry, replication and transcription of the viral genome, and virion assembly and release to identify the pivotal targets for drug development. To study the underlying mechanisms of interplay between viruses and their hosts will also help reveal new drug targets. Innate host immunity is the first line of defense against pathogen infection, playing a critical role in host resistance to pathogenic microorganisms. Interestingly, the viruses have evolved a variety of strategies to antagonize host restriction and escape the innate immune response. The interaction between host antiviral proteins and viral antagonizing proteins constitutes a dynamic and sophisticated network. Thus, strategies that boost the roles of host restriction while diminishing viral antagonism may lead to new therapies against viral infection.

Naoyuki Taniguchi

Osaka International Cancer Institute, Japan

2006-2018 
Group Director, Systems Glycobiology Research Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, Global Research Cluster, RIKEN, Wako, Japan 

2018 
Head, Department of Glyco-Oncology and Medical Biochemistry. Research Center, Osaka International Cancer Institute 

2019 
Director, Research Center, Osaka International Cancer Institute

Google Scholar Citation （As of Sept.27,2022） ） 
Citations 51181 
h-index １１３ 

Jin-ichi Inokuchi

Tohoku Medical and Pharmaceutical University, Japan

Research
The role of glycosphingolipids in inflammation, immune and neural functions. My current research is focused on the pathophysiological roles of glycosphingolipids in metabolic syndrome, innate immune regulation, T cell development and function, and hearing function with a specific focus on membrane microdomains (lipid rafts) and on the development of novel diagnosis and therapeutic intervention based on the discovery in my laboratory.

Awards
Fulbright Award as senior research scientist at University of Michigan (1985-1987)
Research Investigator Award from Fukuoka University (1985)

Jianguo Gu

Tohoku Medical and Pharmaceutical University, Japan

Dr. Gu’s group has been performing extensive studies on the importance of glycans in physiological and pathological conditions, and demonstrates the N-glycans play important roles in cell adhesion, proliferation, and differentiation, as well as in some diseases including cancers and neurological disorders. Recently, his group also works on functional roles of glycans in neuroinflammation and chemoresistance. His group has published over 150 peer-reviewed original papers and review articles. 

Selected recent representative publications: 
1. Bisecting GlcNAc residues on laminin-332 downregulates galectin-3 dependent keratinocyte motility. Kariya, Y., Kawamura, C., Tabei, T., Gu, J. J. Biol. Chem. 285:3330-3340, 2010 
2. Wnt/β-catenin Signaling Down-regulates N-Acetylglucosaminyltransferase III Expression:The implication of two mutually exclusive pathways for regulation. Xu, Q., Akama, R., Isaji, T., Lu, Y., Hashimoto, H., Kariya, Y., Fukuda, T., Du, Y., and Gu, J. J. Biol. Chem. 286: 4310-8, 2011 
3. α1,6-Fucosyltransferase-deficient mice exhibit multiple behavioral abnormalities associated with a schizophrenia-like phenotype: importance of the balance between the dopamine and serotonin systems. Fukuda, T., Hashimoto, H., Okayasu, N., Kameyama, A., Onogi, H., Nakagawasai, O, Nakazawa, T., Kurosawa, T., Hao, Y., Isaji, T., Tadano, T., Narimatsu, H., Taniguchi, N. and Gu, J. J. Biol. Chem. 286: 18434-43, 2011 
4. Core fucosylation of mu heavy chains regulates the assembly of precursor B cell receptors and its intracellular signaling. Li, W., Liu, Q., Pang, Y., Jin, J., Wang, H., Cao, H., Li, Z., Wang, X., Ma, B., Chi, Y., Wang, R., Kondo, A., Gu, J. and Taniguchi, N. J Biol Chem. 287:2500-2508, 2012
5. Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by TGF-β1 in epithelial cell lines. Xu, Q., Isaji, T., Lu, Y., Gu, W., Kondo, M., Fukuda, T., Du, Y. and Gu, J. J Biol Chem. 287:16563-74, 2012
6. α1,6-Fucosylation regulates neurite formation via the activin/phospho-Smad2 pathway in PC12 cells: the implicated dual effects of Fut8 for TGF-β/activin-mediated signaling. Gu, W., Fukuda, T., Isaji, T., Hashimoto, H., Wang., Y and Gu, J. FASEB J., 27:3947-3958, 2013
7. An oncogenic protein Golgi phosphoprotein 3 up-regulates cell migration via sialylation. Isaji, T., Im, S., Gu, W., Wang, Y., Hang, H., Lu, J., Fukuda, T., Hashii, N., Takakura, D., Kawasaki, N., Miyoshi, H. and Gu, J. J. Biol. Chem. 289: 20694-20705, 2014
8. β-Galactoside α2,6 Sialyltranferase 1 Promotes Transforming Growth Factor-β-Mediated Epithelial-Mesenchymal Transition. Lu, J., Isaji, T., Im, S., Fukuda, T., Hashii, N., Takakura, D., Kawasaki, N. and Gu, J. J. Biol. Chem. 289: 34627-34641, 2014
9. Loss of α1,6-fucosyltransferase inhibits chemical-induced hepatocellular carcinoma and tumorigenesis by down-regulating multiple cellular signaling. Wang, Y., Fukuda, T., Isaji, T., Lu, J., Im, S., Hang, Q., Gu, W., Hou, S., Ohtsubo, K. and Gu, J. FASEB J., 29, 3217-27, 2015
10. Integrin α5 suppresses the phosphorylation of epidermal growth factor receptor and its cellular signaling of cell proliferation via N-glycosylation. Hang, Q., Isaji, T., Hou, S., Im, S., Fukuda, T. and Gu, J. J. Biol. Chem. 290, 29345-60, 2015
11. Distinct effects of β1 integrin on cell proliferation and cellular signaling in MDA-MB-231 breast cancer cells. Hou, S., Isaji, T., Hang, Q., Im, S., Fukuda, T. and Gu, J. Sci. Rep. Doi: 10.1038/srep18430, 2016
12. Loss of α1,6-fucosyltransferase decreased hippocampal long-term potentiation: implications for core fucosylation in the regulation of AMPA receptor heteromerization and cellular signaling. Gu, W., Fukuda, T., Isaji, T., Hang, Q., Lee, H., Sakai, S., Morise, J., Mitoma, J., Higashi, H., Taniguchi, N., Yawo, H., Oka, S. and Gu, J. J. Biol. Chem. 290: 17566-75, 2015
13. Expression of N-acetylglucosaminyltransferase III suppresses α2,3 sialylation and its distinctive functions in cell migration are attributed to α2,6 sialylation levels. Lu, J., Isaji, T., Im, S., Fukuda, T., Kameyama, A. and Gu, J. J. Biol. Chem. 291, 5708-20, 2016
14. The importance of membrane-proximal N-glycosylation on integrin β1 in its activation and complex formation. Hou, S., Hang, Q., Isaji, T., Lu, J., Fukuda, T. and Gu, J. FASEB J. 30, 4120-31, 2016
15. N-Glycosylation of integrin α5 acts as a switch for EGFR-mediated complex formation of integrin α5β1 to α6β4. Hang, Q., Isaji, T., Hou, S., Zhou, Y., Fukuda, T. and Gu, J. Sci. Rep. doi: 10.1038/srep33507, 2016
16. A key regulator of cell adhesion: Identification and characterization of important N-glycosylation sites on integrin α5 for cell migration. Hang, Q., Isaji, T., Hou, S., Wang, Y., Fukuda, T. and Gu, J. Mol. Cell. Biol. 37, 558-16, 2017
17. Inhibition of fucosylation by 2-fluorofucose suppresses human liver cancer HepG2 cell proliferation and migration as well as tumor formation. Zhou, Y., Fukuda, T., Hang, Q., Hou, S., Isaji, T., Kameyama, A., and Gu, J. Sci Rep. doi: 10.1038/s41598, 2017
18. N-Acetylglucosaminyltransferase I as a novel regulator of the epithelial-mesenchymal transition. Zhang, G., Isaji, T., Xu, Z., Lu, X., Fukuda, T. and Gu, J. FASEB J., 33: 2823-2835. doi: 10.1096/fj.201801478R, 2018
19. O-GlcNAcylation regulates integrin-mediated cell adhesion and migration via formation of focal adhesion complexes. Xu, Z., Isaji, T., Fukuda, T., Wang, Y. and Gu, J. J. Biol. Chem. 294: 3117-3124, 2019
20. A complex between phosphatidylinositol 4 kinase IIα and integrin α3β1 is required for N-glycan sialylation in cancer cells. Isaji, T., Im, S., Kameyama, A., Wang, Y., Fukuda, T. and Gu, J. J. Biol. Chem. 294: 4425-4436, 2019
21. ST3GAL3, ST3GAL4, and ST3GAL6 differ in their regulation of biological functions via the specificities for the α2,3‐sialylation of target proteins. Qi, F., Isaji, T., Duan, C., Yang, J., Wang, Y., Fukuda, T. and Gu, J. FASEB J., 34: 881-879. 2020
22. Deficiency of core fucosylation activates cellular signaling dependent on FLT3 expression in a Ba/F3 cell system. Duan, C., Fukuda, T., Isaji, T., Qi, F., Yang, J., Wang, Y., Takahashi, S. and Gu, J. FASEB J., 34: 3239-3252. 2020
23. TM4SF1 promotes esophageal squamous cell carcinoma metastasis by interacting with integrin α6. Hou, S., Hao, X., Li, J., Weng, S., Wang, J., Zhao, T., Li, W., Hu, X., Deng, B., Gu, J. and Hang, Q. Cell Death Dis., 13: 609, 2022
24. O-GlcNAcylation Regulates β1,4-GlcNAc-branched N-glycan Biosynthesis Via the OGT/SLC35A3/GnT-IV Axis. Song, W., Isaji, T., Nakano, M., Liang C., Fukuda, T. and Gu, J. FASEB J., 36: e22149. doi: 10.1096/fj.202101520R. 2022

Ying Zhang

Fudan University, China

Research Interests 
Dr. Ying Zhang is Professor of Institutes of Biomedical Sciences and NHC Key Laboratory of Glycoconjugates Research，Fudan University. Her research interest is mainly focuses on developing novel approaches for the analysis of protein glycosylation using mass spectrometry and their application in biomedical sciences. She has published more than 40 peer reviewed papers, including Angew Chem Int Ed, Nat Commun, Chem Sci, Anal Chem, Chem Commun, Chem Sov Rev, and et al.

Awards 
Chang Jiang Scholars Program (Youth Scholar) 
Shanghai Pujiang Scholar 
Shanghai Rising-Star Program 

Selected Publications (* Corresponding author) 
1. Zhenyu Sun, Bin Fu, Guoli Wang, Lei Zhang, Ruofan Xu, Ying Zhang*, Haojie Lu* High-throughput site-specific N-glycoproteomics reveals glyco-signatures for liver disease diagnosis. Nat. Sci. Rev., 2022, https://doi.org/10.1093/nsr/nwac059 
2. Zhenyu Sun, Guanghui Ji, Guoli Wang, Lei Wei, Ying Zhang*, Haojie Lu* One step carboxyl group isotopic labeling for quantitative analysis of intact glycopeptides. Chem. Commun, 2021, 57, 4154-4157 
3. Ying Zhang*, Der-Shyang Kao, Bing Gu, Rajdeep Bomjan, Mayank Srivastava, Haojie Lu, Daoguo Zhou, W. Andy Tao* Tracking pathogen infection by time-resolved chemical proteomics. Angew. Chem. Int. Ed., 2020, 59, 2235 –2240. (Inside Cover) 
4. Mayank Srivastava, Ying Zhang*, Jian Chen, Andrew Miller, Devika Sirohi, Yang Zhang, Haojie Lu, Jianqing Xu*, Richard J. Kuhn* and W. Andy Tao* Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor. Nat. Comm., 2020, 11, 3896
5. Lijun Yang, Lei Zhang, Ye Peng, Yan Cai, Ting Cao, Ying Zhang* and Haojie Lu* Chemical labeling for fine mapping of IgG N-glycosylation by ETD MS. Chem. Sci., 2019, 10, 9302-9307

Xiaolian Zhang

Wuhan University, China

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Wen Yi

Zhejiang University,China

Wen Yi is currently Professor of Biochemistry at the College of Life Sciences, Zhejiang University. He received his Ph.D. degree at the Ohio State University (USA), and worked as a postdoctoral fellow at the California Institute of Technology, before joining Zhejiang University as an independent investigator. His research is focused on developing chemical/biochemical tools to understand the role of protein glycosylation in human health and diseases. He received several prestigious awards, including the Excellent Young Investigator award from the National Natural Science Foundation of China (NSFC), the Young Glycoscientist award from the International Glycoconjugate Organization, the “Zhang Shuzheng Young Glycoscientist” award from the Chinese Bioengineering Society, and the research award from the Mizutani Glycoscience Foundation of Japan.

Taku Okazaki

the University of Tokyo, Japan

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Sho Yamasaki

Osaka University, Japan

Sho Yamasaki is Professor and head of the division of Molecular Immunology. After graduation from Kyoto University (Ms) in 1993, he started immunology research in Mitsubishi Chemical Corporation (1993-1999). In 1999, he received his PhD from Kyoto University for his study with Makio Iwashima on T cell antigen receptor signaling. Then he worked with Takashi Saito at Chiba University and RIKEN RCAI on the signal transduction of immune receptors. In 2009, he started the Molecular Immunology Laboratory at Kyushu University, where he holds the position of professor (2009-2017). He took his current position at Osaka University from 2017. His laboratory focuses on understanding the molecular mechanisms underlying the recognition of internal and external insults through ITAM-coupled immune receptors, such as C-type lection receptors and innate-type T cell receptors. His laboratory is also developing a platform analyzing human T cell clonotypes specific for pathogens.

Yoon Park

Center for Theragnosis, Biomedical Research Institute Korea Institute of Science and Technology (KIST) ,Republic of Korea

Yoon Park is a T cell immunologist and a senior member of Korea Institute of Science and Technology (KIST). She received her PhD at Yonsei university, Korea and completed her postdoctoral fellowship in Dr. Yun-cai Liu’s laboratory at La Jolla Institute for Immunology (LJI), San Diego, USA where she studied Treg cell biology and mechanisms of the immune homeostasis. She then joined Pfizer and later Bristol-Myers Squibb (BMS), San Francisco, USA as a senior research investigator to develop cancer immunotherapies including allogeneic CAR-T cell and immune checkpoint blockade therapies. With her “bench-to-bedside” experience in Immuno-Oncology, she has been studying the mechanism of action of immunotherapy and molecular interplay between multiple immune checkpoint receptors in modulating human T cell responses since moving back to Korea in 2018. In addition, research in her laboratory focuses on discovering novel molecules that mediate immune evasion in human diseases.

Bing Su

Shanghai Jiao Tong University, China

Dr. Bing Su obtained his B.S. degree from Peking University in 1984 and his Ph.D. degree from Yale University in 1991. He did his postdoctoral training with Dr. Michael Karin at the University of California San Diego before starting his academic career in 1995 as an Assistant Professor at the University of Texas M. D. Anderson Cancer Center where he was promoted to a tenured full Professor in 2006. He moved to Yale University in 2006 as a tenured faculty at the Department of Immunobiology until 2014 when he relocated to SJTU in China. Dr. Bing Su is now the Director of Shanghai Institute of Immunology and Chair of Department of Immunology and Microbiology at Shanghai JiaoTong University School of Medicine, Co-Founding Director of Shanghai JiaoTong University School of Medicine-Yale University Institute for Immune Metabolism (SYIIM) and an Adjunct Professor at Department of Immunobiology at Yale University School of Medicine. Dr. Su also holds a KC Wong Chair Professorship at Shanghai JiaoTong University. Dr. Su’s research focuses on the intracellular signal transduction pathways controlled by the mammalian target of rapamycin (mTOR) and the mitogen activated protein kinases (MAPKs). He studies the roles of these intracellular signaling cascades in immune regulation and vascular function. Dr. Su has published over 110 peer-reviewed papers, many of which were in high-impact journals such as Nature, Cell, Nature Genetics, Nature Immunology, Immunity, Molecular Cell, EMBO J, etc., with citation over 15000. His research has been supported from grants awarded by Ministry of National Scinece and Technology (Chief Scientist), as well as National Natural Science Foundation of China (NSFC) and Shanghai Science and Technology Commission. 

Dr. Su is a member of Chinese Biological Investigator Society and a member of Society of Chinese Bioscientists in America (SCBA).He served on many review committees including NIH Study Sections, the Review Committee for the Key Programs of NSFC, etc. He is also the editor-in-chief of Current Immunology, and the associate editor of Journal of Molecular Cell Biology and Current Research in Immunology.

Chenqi Xu

Centre for Excellence in Molecular Cell Science, CAS, China

Chenqi Xu completed his PhD training in protein chemistry with Dr. Chengwu Chi in 2004 at SIBCB. A part of his PhD work was done in University of Leuven and University of Hasselt in Belgium, under supervision of Drs. Jan Tytgat and Emmy Van Kerkhove. He then received postdoctoral training in immunology with Dr. Kai Wucherpfennig at Dana Farber Cancer Institute, Harvard Medical School. In 2009, he moved back to SIBCB to start his independent career. 

Chenqi Xu studies T-cell signaling and metabolism, with the goal of developing next-generation immunotherapies. His discovers new regulatory mechanisms of key immunoreceptors, including TCR, CD28 and PD-1, and demonstrates the contribution of cholesterol metabolism in T-cell antitumor immunity. He has developed several new strategies of cancer immunotherapy, such as the Hybrid CAR-T therapy. Given his outstanding contributions to the field, he received several prestigious awards such as the China Youth Science and Technology Award and the Promega Award for Biochemistry.

Youhai Chen

Shenzhen Institute of Advanced Technology, CAS, China

Dr. Chen received his medical school training from the Shandong University and his Ph.D. training from the University of Manitoba (Canada). After a successful postdoctoral training at Harvard University, he joined the faculty of the University of Pennsylvania in 1995. He was a tenured Professor of Pathology and Laboratory Medicine at University of Pennsylvania until 2020 when he joined the Shenzhen Institute of Advanced Technology as its founding Dean of Faculty of Pharmaceutical Sciences. Dr. Chen is a renowned immunologist who has made lasting impacts on immunological research. He has published more than 160 research articles with a total citation >18000 and an H-index of 66 (Google Scholar); he is ranked by the Stanford University as one of the Top 1% Scientists for Lifetime Scientific Impact; he is an elected Member of Academia Europaea, elected Fellow of the American Institute for Medical and Biological Engineering, elected Member of the Kunkel Society, recipient of the Colyton Prize for Autoimmune Research, and invited speaker for more than 100 international meetings. Dr. Chen’s major high-impact contributions to science include: 
(I) He discovered a subset of T lymphocytes called regulatory T cells that secret transforming growth factor-beta and reported a paradigm-shifting concept that regulatory T cell development is specified by a lineage-specific “enhanceosome” (Science, 265: 1237, 1994 - cited for 2484 times; Immunity 31: 932, 2009 - cited for 406 times); these fundamental discoveries helped establish the current paradigm of regulatory T cell biology and made a major impact on our understanding of immune tolerance in general. 
(II) He discovered crucial roles of TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) in autoimmunity and liver failure (Nature Immunology 4:255, 2003; Journal of Clinical Investigation 113:58, 2004), and developed the first TRAIL-blocking antibody drug that is being tested in phase I clinical trials for treating hepatitis and liver failure, which afflict millions of people worldwide.
(III) He discovered and characterized three members of the TIPE (TNF-a-induced Protein 8-like) family (Cell 133:415, 2008; Nature Immunology 18: 1353, 2017): by genomic profiling of inflamed tissue, Dr. Chen’s laboratory identified, in 2008, three novel members of the TIPE family. They have since crystallized two of them and generated mice deficient in all of them. They discovered that TIPE family plays essential roles in colitis, encephalomyelitis, and carcinogenesis; They found that TIPE family is the transfer proteins of lipid second messengers PIP2 and PIP3. These ground-breaking discoveries helped deepen our understanding of the molecular pathways shared by inflammation and cancer, and provided new therapeutic opportunities for treating inflammatory and neoplastic diseases.

Representative Papers in Recent Five Years：
Fayngerts Svetlana A; Wang Zhaojun; Zamani Ali; Sun Honghong; Boggs Amanda E; Porturas homas P; Xie Weidong; Lin Mei; Cathopoulis Terry; Goldsmith Jason R; Vourekas Anastassios; Chen Youhai H.; Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2, Nature Immunology, 2017, 18(12): 1353-1360.
Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W. Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response, Nature, 2018, 560(7718): 382-386.
Li Ting; Li Xinyuan; Zamani Ali; Wang Wei; Lee Chin-Nien; Li Mingyue; Luo George; Eiler Emily; Sun Honghong; Ghosh Sankar; Jin Jian; Murali Ramachandran; Ruan Qingguo; Shi Weiyun; Chen Youhai H.; c-Rel is a myeloid checkpoint for cancer immunotherapy, Nature Cancer, 2020, 1(5): 507-517.
Wang Y, Zhang H, Wang Z, Wei Y, Wang M, Liu M, Wang X, Jiang Y, Shi G, Zhao D, Yang Z, Ren Z, Li J, Zhang Z, Wang Z, Zhang B, Zong B, Lou X, Liu C, Wang Z, Zhang H, Tao N, Li X, Zhang X, Guo Y, Ye Y, Qi Y, Li H, Wang M, Guo R, Cheng G, Li S, Zhang J, Liu G, Chai L, Lou Q, Li X, Cui X, Gao E, Dong Z, Hu Y, Chen YH, Ma Y.; Blocking the death checkpoint protein TRAIL improves cardiac function after myocardial infarction in monkeys, pigs, and rats. Science Translational Medicine 12: aaw3172, 2020.
Goldsmith Jason R.; Spitofsky Nina; Zamani Ali; Hood Ryan; Boggs Amanda; Li Xinyuan; Li Mingyue; Reiner Elizabeth; Ayyaz Arshad; Etwebi Zienab; Lu Ling; Rivera Guzman Javier; Bou-Dargham Mayassa J.; Cathoupolis Terry; Hakonarson Hakon; Sun Honghong; Wrana Jeffrey L; Gonzalez Michael V; Chen Youhai H.; TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling, Nature Communications, 2020, 11(1): 2591.

Hye Ryun Woo

Daegu Gyeongbuk Institute of Science & Technology, Republic of Korea

Research interests 
Epigenetic regulatory mechanisms on leaf senescence Molecular genetic regulation multi-stress responses in plants Coordination programs for leaf growth and senescence in Arabidopsis

Selected publications 
Park, SJ; Park, SH; Kim, YM; Hyeon, DY; Park, HS; Jeong, JY; Jeong, UC, Yoon, YS; You, DS; Kwak, JM; Timilsina, R; Hwang, DH; Kim, JS; Woo, HR* (2022) ETHYLENE RESPONSIVE FACTOR 34 mediates stress-induced leaf senescence by regulating salt stress-responsive genes, Plant, Cell & Environ., vol.45, no.6, pp. 1719~1733 
Timilsina, R; Kim, YM; Park, SH; Park, HS; Park, SJ; Kim, JH; Park, JH; Kim, DA; Park, YI; Hwang, DH; Lee, JC; Woo, HR* (2022) ORESARA 15, a PLATZ transcription factor, controls root meristem size through auxin and cytokinin signalling-related pathways, J. Exp. Bot., vol. 73, no.8, pp. 2511~2524 
Li, ZH; Kim, JH; Kim, JS; Lyu, JI; Zhang, Y; Guo, HW; Nam, HG*; Woo, HR* (2020) ATM suppresses leaf senescence triggered by DNA double-strand break through epigenetic control of senescence-associated genes in Arabidopsis, New Phytol., vol.227, no.2, pp.473~484 
Woo, HR; Kim, HJ; Lim, PO; Nam, HG (2019) Leaf Senescence: Systems and Dynamics Aspects, Annu. Rev. Plant Biol., vol.70, pp.347~376 
Kim, JH; Kim, J; Jun, SE; Park, SH; Timilsina, R; Kwon, DS; Kim, YM; Park, SJ; Hwang, JY; Nam, HG; Kim, GT*; Woo, HR* (2018) ORESARA15, a PLATZ transcription factor, mediates leaf growth and senescence in Arabidopsis, New Phytol., vol.220, no.2, pp.609~623
Kim, HJ; Park, JH; Kim, J; Kim, JJ; Hong, S; Kim, J; Kim, JH; Woo, HR; Hyeon, C; Lim, P. O.; Nam, HG; Hwang, DH (2018) Time-evolving genetic networks reveal a NAC troika that negatively regulates leaf senescence in Arabidopsis, Proc. Natl Acad. Sci. USA, vol.115, no.21, pp.E4930~E4939
Kim, JS; Park, SJ; Lee, IH; Chu, H; Penfold, CA; Kim, J; Buchanan-Wollaston, V; Nam, HG; Woo, HR*; Lim, PO* (2018) Comparative transcriptome analysis in Arabidopsis ein2/ore3 and ahk3/ore12 mutants during dark-induced leaf senescence, J. Exp. Bot., vol.69, no.12, pp.3023~3036 

Tatsuo Kakimoto

Osaka University, Japan

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Teerapong Buaboocha

Chulalongkorn University,Thailand

Associate Professor Dr.Teerapong Buaboocha obtained his Ph.D. degree in Plant Biology from University of Illinois at Urbana-Champaign, Illinois, USA. He started his career as a lecturer in the Department of Biochemistry, Faculty of Science, Chulalongkorn University where he was appointed Associate Professor of Biochemistry until present. Currently, he serves as head of the Department and Chair of the Biochemistry and Molecular Biology section, the Science Society of Thailand. 

He has targeted his research on genomics and post-genomics analysis of plant stress responses. Current focuses are on using genome-wide association and bulked segregant analysis to identify salt-tolerant genes from local Thai rice, and transcriptome profiling and a range of molecular approaches to investigate the mechanisms of signaling and responses to salt stress.

Xiaofeng Fang

Tsinghua University, China

Research interest 
The biomolecular condensates are emerging as a central way for cellular compartmentalization. Most of the biomolecular condensates are assembled via liquid-liquid phase separation (LLPS). Using a combination of genetics, biochemistry, cell biology and bioinformatics, my lab is focusing on the assembly and biological functions of biomolecular condensates in plant development and stress responses. 

Selected publications 
Lin Y*, Fang X*. (2021) Phase Separation in RNA Biology. J Genet Genomics. doi: 10.1016/j.jgg.2021.07.012. (Invited Review) 
Li C, Fang X*. (2020) Phase Separation as a Molecular Thermosensor. Dev Cell. 55(2):118-119. (Invited Comments) 
Fang X*, Wu Z, Raitskin O, Webb K, Voigt P, Lu T, Howard M, Dean C (2020) The 3' processing of antisense RNAs physically links to chromatin-based transcriptional control. PNAS. 117(26):15316-15321. (*co-corresponding author) 
Yang M#, Woolfenden HC#, Zhang Y#, Fang X#, Liu Q, Vigh ML, Cheema J, Yang X, Norris M, Yu S, Carbonell A, Brodersen P, Wang J, & Ding Y (2020) Intact RNA structurome reveals mRNA structure-mediated regulation of miRNA cleavage in vivo. Nucleic Acids Res. gkaa577. (#co-first author) 
Fang X#, Wang L#, Ishikawa R#, Li Y, Fiedler M, Liu F, Calder G, Rowan B, Weigel D, Li P, Dean C. (2019) Arabidopsis FLL2 promotes liquid-liquid phase separation of polyadenylation complexes. Nature. 569(7755): 265-269 (#co-first author) 
Fang X#, Zhao G#, Zhang S, Li Y, Gu H, Li Y, Zhao Q, Qi Y (2018) Chloroplast-to-nucleus signaling regulates microRNA biogenesis in Arabidopsis. Developmental Cell. 48, 371-382. (#co-first author)

Shuhua Yang

China Agricultural University,China

Shuhua Yang is a professor in the College of Biological Science, China Agricultural University. She received B.S. and M.S. degrees at Nankai University, China, and a Ph.D degree at National University of Singapore. After completing postdoctoral research at Cornell University, she joined the faculty at China Agricultural University. She is currently the Director for the State Key Laboratory of Plant Physiology and Biochemistry. She is an editorial board member of several journals, including Plant Cell, New Phytologist, and JIPB. Her laboratory mainly focuses on the study of molecular mechanism of plant responses to low temperatures using Arabidopsis thaliana and maize as research systems. She is also investigating the crosstalk of cold and light signaling, as well as cold and plant hormone signaling. Her research aims at deep understanding of how plants perceive and respond to the environmental temperature change.

Jiankang Zhu

Southern University of Science and Technology, China

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Robert E. Campbell

University of Tokyo, Japan

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Jihye Seong

KIST Brain Science Institute, Republic of Korea

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Mako KAMIYA

Tokyo Institute of Technology, Japan

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Xianjun Chen

East China University of Science and Technology, China

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Junke Zheng

Shanghai Jiao Tong University, China

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Kiryl D. Piatkevich

Westlake University, China

Kiryl Piatkevich received an M.S. degree in Chemistry at Lomonosov Moscow State University. Then he enrolled in a joint Ph.D. program between Albert Einstein College of Medicine in New York and Lomonosov Moscow State University to work on the development of fluorescent proteins for multicolor intravital two-photon imaging under the supervision of Vladislav Verkhusha and Sergei Varfolomeev. After completing of his graduate work, Kiryl Piatkevich joined Synthetic Neurobiology group led by Ed Boyden at MIT. His postdoctoral work was focused on engineering new scalable molecular and imaging technologies for mapping brain computations. Starting 2019, Dr. Piatkevich leads the Molecular BioEngineering Group (www.piatkevich-lab.com) in the School of Life Science at Westlake University, which develops cutting-edge optical technologies for analyzing, controlling, and repairing complex biological systems such as the brain. His group also applies developed technologies systematically to reveal underpinning molecular mechanisms of brain disorders as well as understand ground truth principles of neural codes. Our ultimate goal is to create novel scalable technologies that will offer a new paradigm for probing both functional and structural properties of biological systems to enable a better understanding of the causal correlations between activity and structure in defined cellular ensembles.

Guizhen Wu

Chinese Centre for Disease Control and Prevention, China

武桂珍研究员，亚太生物安全协会主席，中国疾病预防控制中心生物安全首席专家，世界卫生组织生物安全咨询专家委员会委员。 

数十年致力于生物安全和重大传染病防控研究，是我国实验室生物安全管理体系的主要策划和创建者。自2004年以来，凭借她一系列开创性的工作，中国CDC乃至中国的实验室生物安全管理几年间由分散、无序发展为集中、规范、科学的全方位管理体系，强力支撑新冠肺炎、埃博拉等重大疫情高效应对，为人民健康做出重大贡献。新冠疫情发生以来，率队一周内完成全基因组测定、核酸检测试剂研发、病毒成功分离，第一时间向全球共享新冠病毒基因序列，自此以后，全球新冠疫苗、诊断试剂和药物研发才相继开始；主持研发全球首个新冠灭活疫苗（BBIBP-CorV），上述贡献为全球新冠抗疫作出了中国贡献，被授予“全国抗击新冠肺炎疫情先进个人”荣誉称号。 

主持制/修订我国10余部生物安全法规标准，主编15部专著。以通讯（含共同）作者在Nature、Science、Cell、NEJM、Lancet等期刊发表论文100余篇。创办我国首个生物安全专业英文期刊Biosafety and Health并任主编。 

获得卫生部有突出贡献中青年专家、全国三八红旗手等荣誉，享受国务院政府特殊津贴。荣获国家科技进步特等奖1项，省部级科技奖7项。 

Professor Guizhen Wu, President of Asia-Pacific Biosafety Association (A-PBA), China CDC’s Chief Expert of Biosafety Control, Member of WHO Technical Advisory Group for Biosafety (TAG-B), has been working for nearly four decades in the field of public health emergencies and laboratory biosafety.

Wu is the major planners and promoters of the construction of laboratory biosafety management system in China. With her pioneering efforts, a comprehensive, centralized, standardized, and scientific laboratory management system has been established in China CDC and followed by establishment at all levels of CDCs since 2004. Based on the system, she has presided over the efficient disposal of emerging infectious diseases, including the pandemic H1N1 influenza, Ebola outbreak in West Afraica, and the coronavirus disease 2019 (COVID-19), etc., making a significant contribution to people’s health.

To respond promptly to the initial outbreak of COVID-19 in late December, 2019, Wu led the specialists in IVDC to sequence the virus genome, develop diagnostic reagents, and successfully isolate the virus in 7 days. The genetic sequence was shared globally in the first time, since then the development of most COVID-19 vaccines and diagnostic agents was initiated around the world. Wu also successfully led the development of a safe and effective COVID-19 vaccine (BBIBP-CorV), which was listed for emergency use by WHO in 2021. These four major achievements have been recognized as China's major contributions to the global efforts against the COVID-19 pandemic. With her outstanding performance in response to COVID-19, Wu was recognized and awarded as the "national advanced individual in combating COVID-19" in China.

Wu and her team also participated in drafting and revising more than 10 relevant laws, regulations, and standards. She authored more than 100 papers in Nature, Science, Cell, NEJM, Lancet and other international journals as correspondence. As Editor-in-Chief, Wu published 15 biosafety-related monographs including the recently published Laboratory Biosafety Guide, and initiated a scientific journal in English, namely Biosafety and Health in 2019, which periodically published the academic findings in the field of biosafety. In January 2022, Wu was selected as the world's top 100,000 scientists (ranking first in China in the field of public health and Preventive Medicine).

Wu was rewarded the Special Government Allowance from the State Council of China and awarded the Outstanding Young and Middle-Aged Expert by the Ministry of Health (now the NHC) of China. She has also won the National Prize for Scientific and Technological Progress (Special Class and First-Class) and seven provincial and ministerial science and technology awards.

As China CDC’s Chief Expert of Biosafety Control, Wu collaborates and shares with the World Health Organization (WHO), European Biosafety Association (EBSA), and American Biological Safety Association International (ABSA). She continues to play a crucial role in guiding China’s biosafety development and safeguarding the country in response to emerging and reemerging infectious diseases.

Chengyu Jiang

Peking Union Medical College,China

Chengyu Jiang is a professor and chair of biochemistry department at Peking Union Medical College and Chinese Academy of Medical Sciences (PUMC/CAMS). She obtained her B.S from University of Science and Technology of China, and PhD at Brown University, followed by postdoctoral training at Massachusettes General Hospotal, affliated to Harvard Medical Scholl before joining PUMC/CAMS. She received numerous hornors including Changjiang Distinguished Professor and National Outstanding Young Award Fund. She is the chief scientist of the National Key Basic Research Development Plan (973 Plan) in respiratory diseases, and the president of Beijing Society of Biochemistry and Molecular Biology. 

Chengyu Jiang’s research focuses on the pharmacology of small RNA, a new component of botanical medicine, and the diseases related to lung injury, especially its severe form acute respiratory distress syndrome (ARDS) associated with a high mortality rate (20-50%). Jiang’s team analyzed the molecular pathways of severe pneumonia and ARDS, established and exploited the potential intervention targets and biomarkers, and identified existing drugs that may be repurposed for the clinical treatment of ARDS. She published extensively in peer-reviewed journals including Nature, Nature Medicine, Molecular Psychiatry, Cell Research, Nature Communications. The research findings have been granted 7 patents from US, Japan, European Union and China. Some of the patents are exclusively licensed to top 5 international pharmaceutical and biotech companies.

Tao Dong

Oxford University, UK

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Chaolan Huang

National Centre for Protein Science Beijing, China

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Zhongyi Wu

Sun Yat-sen University (/Academia Sinica),China

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Ashfaqul HOQUE

St Vincent’s Institute of Medical Research, Melbourne Australia

Dr Ashfaqul Hoque is a Postdoctoral Fellow working at the Metabolic Signalling Laboratory of St Vincent’s Institute of Medical Research (SVI). Dr Hoque’s research focuses on investigating the regulatory mechanisms of an important cellular enzyme called AMP-activated protein kinase (AMPK). The goal is to understand how AMPK cooperates with its upstream regulator and downstream effector molecules to act as a cellular ‘detection system’ to sense environmental stresses and availability of nutrients. AMPK, the master regulator of cellular energy homeostasis, is an attractive drug target for diseases such as type 2 diabetes, cancer, cardiovascular and neurodegenerative diseases. Deciphering the molecular mechanisms underlying cell death processes associated with neurological conditions is a key aspect of Dr Hoque’s research. Dr Hoque utilises state-of-the-art mass spectrometry-based quantitative phosphoproteomics together with targeted biochemical approaches in cellular and animal model systems to address research questions.

Lai Yue CHAN

Institute for Molecular Bioscience, University of Queensland, Australia

Dr Lai Yue Angeline Chan completed her PhD in 2012 at the University of Queensland in the field of biochemistry. She is currently a senior postdoctoral fellow at the Institute for Molecular Bioscience and affiliated to the Australian Research Council Centre of Excellence for Innovations in Peptides and Protein Science (ARC CIPPS). She is a recipient of IUBMB MilliporeSigma Virtual Meeting Fellowship, Advance Queensland Women’s Academic Fund and International Young Scientist Program Fellowship. She has extensive experience in peptide/analytical chemistry, proteomics, peptide structure analysis using nuclear magnetic resonance and circular dichroism techniques, and a range of in vitro/in vivo assay development. Her main research interest is to discover nature-inspired peptides and develop them into drugs for targeting human diseases. Most of her work involved peptides from plants (e.g., gourd family, sunflowers, and violets), wasps, spiders and bacteria. These studies have made large contributions to the understanding of sequence diversity of a range of disulfide-rich peptides, structure-activity relationships, and for reengineering process. Overall, her research highlights the potential of these peptide therapeutics for the treatment of cancer, chronic wound, obesity, heart and infectious diseases.

Naveen VANKADARI

University of Melbourne, Australia

Dr. Naveen is a research fellow at the University of Melbourne. He completed post-doctoral research at Monash University in Australia after receiving his PhD in biochemistry, structural and molecular biology from the prestigious Academia Sinica and the National Defense Medical Center in Taiwan. Naveen also has extensive BioTech industry experience as an R&D scientist and production in-charge for Microbial Molecular research at MerckMillpore. Naveen's current research is primarily focused on key events in human infection. In particular, structural and functional studies on viral and bacterial proteins involved in infection have challenged human immunity. This has important implications for understanding disease progression in humans and gives hints about how to regulate it. His research has received global recognition with several awards and prizes in academia and industrial research. His primary research technical areas include cryo-electron microscopy (Cryo-EM), X-ray crystallography, protein biochemistry, clinical trials, computational biology, and biophysical techniques (SPR, ITC, MALS, SAXS, MST). Naveen is also an expert on DNA/RNA-Protein interactions that are specific to translational regulation and how to decipher their functional significance for enhancing their physiological role. His current research focuses on molecular and structural virology, unravelling the entry mechanics of SARS-Cov-2 and other viruses.\

Ibrahim JAVED

University of Queensland, Australia

Dr Javed did his PhD from Monash Institute of Pharmaceutical Sciences. He is currently working as NHMRC Emerging Leadership Fellow at the Australian Institute for Bioengineering and Nanotechnology, at the University of Queensland, Australia. He is leading a team of researchers to explore the biomolecular and cellular events that participate in the bidirectional communications between gut bacteria and the brain. The broad term implications of this research are to elucidate (1) how gut bacteria participate in brain diseases and (2) how we can exploit gut bacteria for therapeutic advantages, either through symbiotic microbes or smart medicine.

Tahirah YASMIN

University of Dhaka, Bangladesh

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Prof. Gabriel Hornink

Federal University of Alfenas, Brazil

Holds a BSc in Biological Sciences from the University of Campinas-Unicamp-Brazil, specializing in environmental management from Unicamp, Master of Functional and Molecular Biology (Biochemistry, subarea Education) and PhD in Science, both at Unicamp. Postdoctoral studies were carried out at the University of Minho (Portugal), at the Institute of Education, within the scope of the Center for Innovation and Development of Teaching and Learning. Research in the area of digital educational technologies, including: teacher training for the use of computer science in education; development and evaluation of educational software; authoring system (programming principles); distance learning. Coordinates the Beer with Science extension project. Work as coeditor of the Journal of Biochemistry Education. Currently, work as a professor of Biochemistry, Beer Science and Educational Technologies at the Federal University of Alfenas and lead the group Technological Innovations in Education. Participates also in the Biochemical InterAction research group. Also work as a professor in the Program in Education (Master degree) and specialization in Technology and Quality in Food Production. 

in case the text is inserted in some site, you can insert the links Curriculum: http://lattes.cnpq.br/7615930937088442 / https://www.researchgate.net/profile/Gabriel-Hornink www.bioquimica.org.br

Prof. Xiao-Yun Lu

School of Life Science and Technology, Xi’an Jiaotong University,China

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Prof. Rongwu Yang

School of Life Sciences, Nanjing University,China

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Prof. Cong-Zhao Zhou

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Archa Fox

The University of Western Australia, Australia

Archa Fox is Professor and Australian Research Council Future Fellow at the University of Western Australia, where she has been running a lab for 15 years. Archa received her PhD in 2000 from The University of Sydney, Australia, and did her Post-doctoral work with Prof Angus Lamond at the University of Dundee, Scotland, UK. She is most well known for her discovery, during her post-doc, of RNA-seeded ‘paraspeckle’ nuclear bodies. Her research career has focused on paraspeckle structure and function, leading her into many sub-fields including long noncoding RNA biology, phase separation and RNA therapeutics. She is Chair of the RNA Network of Australia and was an elected Director of the Board for the International RNA Society (2020-21). She recently Co-chaired a Roundtable discussion hosted by the Australian Academy of Science on RNA Biotechnology and was given the emerging leader award of the Australian/NZ Society of Cell and Developmental Biology in 2017.

Joon Kim

Laboratory of Biochemistry, Division of Life Sciences, Korea University, Republic of Korea

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Shengcai Lin

Xiamen University,China

1980-1984 B.S., Biology, Xiamen (Amoy) University  
1984-1985 English Language, Zhongshan University 
1985-1991 Ph.D., Biochemistry, University of Texas Southwestern Medical Center at Dallas 
1991-1995 Associate, Howard Hughes Medical Institute, University of California, San Diego 
1995- 2001 Senior Scientist (Assistant Professor), Institute of Molecular and Cell Biology (IMCB), National University of Singapore 
2001-06 Assistant/Associate Professor (with tenure), Department of Biochemistry, Hong Kong University of Science& Technology 
2001-Present: Cheung Kong Scholar, School of Life Sciences, Xiamen University; 
2021： Fellow of the Chinese Academy of Sciences
   

George Fu Gao

Institute of Microbiology,CAS,China

Prof. Gao Fu is a member (academician) of the Chinese Academy of Sciences (CAS), international member of the U.S. National Academy of Sciences (NAS), foreign member of the U.K. Royal Society (RS) and member of the German National Academy of Sciences Leopoldina. He also serves as vice president, National Natural Science Foundation of China, and director and professor of the CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology. Gao obtained his DPhil degree from Oxford University, UK and did his postdoc work in both Oxford University and Harvard University (with a brief stay in Calgary University). His researches focus on pathogen microbiology and immunology. Gao is a leading scientist in the field of virology and immunology in China and worldwide, and he has long been engaged in the research of transmission of pathogenic microorganisms across hosts, infection mechanisms and host cellular immunity, as well as public health policy and global health strategy, including Influenza, MERS, Ebola, Zika, Chikungunya, and especially for COVID-19 pandemic’s prevention and control. He has published numeral refereed papers (Including papers in Cell, Nature, Science, The Lancet, New England Journal of Medicine, Proceedings of the National Academy of Sciences USA etc.). Gao is a recipient of several international and national awards, including TWAS Medical Prize (2012), Nikkei Asian Prize (Japan 2014), Tan Jiazhen (C. C. Tan) Grand Achievement Prize (2014) and Life Science Innovation Award (2008), Shulan Medical Sciences Award (2016), HLHL Foundation for Scientific and Technological Advancement (2015), the Gamaleya Medal (Russia 2018), HKU Centennial Distinguished Chinese Scholar (2019), the Qiu Shi Outstanding Scientist, Outstanding Scientific Research Team Awards (2019) and TWAS Medal Lectures (2022).